Istanbul to Prague is about 1,551 km and usually takes around 2h 30m in the air. The track it follows runs over the Balkans, the Black Sea, the Eastern European plains, and Central Europe.
Over the Black Sea, the Balkans, the Eastern European plains, and Central Europe the air is usually calm and settled. This track threads jet-stream latitudes, so in winter you may feel a few minutes of light, choppy air high up; summer usually rides calmer.
For most of a flight this length you are at a steady cruise above the weather, where the ride is smooth; the livelier moments, if any, are short.